Babesiosis mu agalu: chithandizo

 Pochiza agalu omwe akudwala babesiosis, mankhwala ambiri osiyanasiyana ayesedwa ndi zotsatira zosiyanasiyana. 

Komabe, zotumphukira za diamidine zomwe zimagwiritsidwa ntchito pochiza canine babesiosis (berenil, batryzin, verbiben, azidin, etc.) zimakhala ndi ntchito yayikulu. Yogwira pophika mankhwalawa ndi diminazene aceturate. Azidine ali 100% yogwira pophika. Berenil amapangidwa mu mawonekedwe a granules, 23,6 g yomwe ili ndi 10,5 g ya chinthu chogwira ntchito. Batrizin amapangidwa mu mawonekedwe a granules, 10,5 g yomwe ili ndi 4,66 g ya chinthu chogwira ntchito. Veriben imapangidwa mu mawonekedwe a granules, 2,36 g yomwe ili ndi 1,05 g ya chinthu chogwira ntchito. Azidine, berenil ndi batryzine ali m'gulu la "B" ponena za poizoni. Mlingo wapamwamba kwambiri wa mbewa ndi 40 mg / kg, akalulu - 25-30 mg / kg, agalu, ng'ombe ndi akavalo - 10 mg / kg. Mankhwala alibe kutchulidwa zilumikizidwe zotsatira, koma mkulu Mlingo amayambitsa poizoni, yodziwika ndi chisokonezo chapakati mantha dongosolo: zimandilimbikitsa kukomoka, ataxia, ndipo nthawi zina kusanza. Veriben ndi wa mankhwala omwe ali oopsa kwambiri kwa nyama zamagazi ofunda. Mankhwala amaunjikana makamaka mu chiwindi ndi impso, pang'ono mu ubongo ndipo excreted makamaka mu mkodzo. Zochita za mankhwalawa zimatengera kuletsa kwa aerobic glycolysis ndi kaphatikizidwe ka DNA mu protozoa ya pathogenic, zomwe zimakhudza kapangidwe kake ndi ntchito ya nembanemba zama cell. Tizilombo tolimbana ndi berenil ndizomwe zimapangitsa kuti zamoyo zizikhala ndi moyo. Chotuluka chachiwiri cha diamidine, chomwe chimagwira ntchito motsutsana ndi B. canis, ndi mitundu ina ya matenda - pentamidine, amagwiritsidwa ntchito pa mlingo wa 16,5 mg / kg kawiri ndi nthawi ya tsiku ndi tsiku. Pogwiritsa ntchito, zotsatira zoyipa monga kupweteka kwa jekeseni, tachycardia, nseru ndi kusanza ndizotheka. Mankhwala othandiza kwambiri polimbana ndi B. canis ndi imidocarb (yochokera ku carbanilide) yogwiritsidwa ntchito pa mlingo wa 5 mg/kg. Malinga ndi olemba ena, berenyl ndi azidine samatenthetsa thupi la nyama piroplasmids ndi kuteteza babesiosis pamene kutumikiridwa 5-10 ndipo ngakhale masiku 17 pamaso pa matenda. Malinga ndi DA Strashnova (1975), berenil pa mlingo wa 7 mg/kg wa kulemera kwa thupi amateteza matenda a agalu ndi tizilombo toyambitsa matenda B. canis mkati mwa masiku 15. Komabe, kasamalidwe ka berenyl pazifukwa zodzitetezera nthawi imodzi ndi magazi owukira sikunawononge thupi la agalu kuchokera ku B. canis, koma, komabe, kuchulukitsa kwa tizilombo toyambitsa matenda m'magazi kumachepa kwambiri. Kuchepetsa mphamvu ya pathological chifukwa cha ntchito yofunikira ya majeremusi ndi kufa kwawo kwakukulu pambuyo popereka mankhwala odana ndi ana, komanso kuchepetsa poizoni wa mankhwala a protistocidal, chithandizo chamankhwala chosiyanasiyana chiyenera kugwiritsidwa ntchito. Pofuna kupititsa patsogolo ntchito ya mtima, njira zosiyanasiyana zokonzekera mtima zimagwiritsidwa ntchito. Nthawi zambiri, sulfocamphocaine ntchito mu mawonekedwe a 10% njira subcutaneously kapena intramuscularly pa mlingo wa 1,0 ml pa 20 makilogalamu a galu moyo kulemera. Mankhwala kutumikiridwa 1-2 zina pa nthawi yonse ya mankhwala. Mankhwala ena amtima (riboxin, cordiamin, camphor) amagwiritsidwanso ntchito. Kuti muchepetse kuledzera, gamavit imagwiritsidwa ntchito, yomwe imakhala ndi 20 amino acid, mavitamini 17, zidutswa za nucleic acid, trace elements, komanso placental extract ndi immunostimulant (sodium nucleinate). Zizindikiro zazikulu zogwiritsira ntchito gamavit ndi katundu wake monga detoxicant, zomwe zimatsimikizira kuti neutralization ndi kuchotsedwa kwa zinthu zowonongeka zapoizoni, ndi kusinthasintha ntchito zomwe zimasokonekera chifukwa cha kuwonekera kwawo. Gamavit imathandizira kubwezeretsanso ntchito ya hematopoietic mu babesiosis. ₉) ndi L-glutamic acid, imakhudzidwa ndi kusunga hematopoiesis. Mankhwalawa ayenera kuperekedwa pansi pa khungu pa mlingo wa 0,1 ml / kg kulemera kwa thupi kwa masiku 5-7. Nthawi zambiri, edema ya ziwalo zosiyanasiyana za thupi mwa agalu ndi kukha magazi pa mucous nembanemba zimakhala ndi chiyambi chofanana ndipo zimachitika chifukwa cha kuchuluka kwa mitsempha yamagazi chifukwa cha kukhudzana ndi poizoni. Kubwezeretsa kukhulupirika ndikupewa kuphwanya kwa makoma a mtima, etamsylate (dicinone) imagwiritsidwa ntchito ngati yankho la 12,5% intramuscularly. The mankhwala kutumikiridwa pa mlingo wa 1,0 ml pa 20 makilogalamu thupi kamodzi pa tsiku loyamba 2-3 masiku a mankhwala. Matenda a meningeal omwe amalembedwa mwa agalu ena mwina amayamba chifukwa cha kukula kwa microflora ya mwayi chifukwa cha kuchepa kwa kukana kwa chiweto chodwala. Choncho, pofuna kupewa kupezeka kwa zizindikiro zovuta, m'pofunika kugwiritsa ntchito antimicrobial agents. Kutengera izi, jakisoni wa benzylpenicillin sodium mchere ayenera kuphatikizidwa mu njira ya mankhwala babesiosis kupewa meningeal zochitika agalu. The mankhwala kutumikiridwa intramuscularly pa mlingo wa 10-15 zikwi mayunitsi pa makilogalamu thupi lililonse 6 hours, kuyambira mlingo woyamba wa nyama, nthawi yonse ya mankhwala. Ma antihistamines ndi corticosteroids (dexamethasone, prednisolone) amagwiritsidwa ntchito kuti achepetse kuyankha kwathunthu kwa kutupa. Amadziwika kuti nthawi yaitali ntchito corticosteroids zingachititse kuphwanya madzi sodium kagayidwe mu thupi kapena kuchititsa chopinga wa ntchito ya adrenal kotekisi. Choncho, pofuna kupewa zinthu izi, mu masiku awiri apitawo mankhwala kutumikiridwa mu amachepetsa Mlingo. Kusunga chiwindi ntchito agalu odwala, Essentiale forte amagwiritsidwanso ntchito pa mlingo wa 3-5 ml pa nyama m`nsinga kwa masiku 5-7.

Onaninso:

Babesiosis ndi chiyani ndipo nkhupakupa za ixodid zimakhala kuti

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Babesiosis mu agalu: zizindikiro

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